A New Approach toward the Realization of Specific and Label‐Free Biological Sensing Based on Field‐Effect Devices

Specific and label-free detection of biological interactions is paramount to a plethora technological applications ranging from home-care diagnostics smart agriculture home security. The biologically-modified field-effect transistor (BioFET) promising sensing platform due its inherent signal amplification, low power, miniaturization. In the following low-cost meta-nano-channel BioFET (MNC BioFET) reported that provides means electrostatically control size, shape, location conducting channel such as enhance coupling between locally-occurring electrostatics electrodynamics underlying channel. Moreover, it Debye screening length at area increase readout signal. MNC fabricated in large-scale silicon chip foundry ensures robustness stability, optimal noise levels repeatability, ultimate miniaturization with potential for high-end multiplexing ultra-small samples. current study, specific prostate antigen demonstrated, show dependency sensor on configuration. Finally, an order magnitude enhancement demonstrated by electrostatic area.